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Efectos de la administración de calcio durante la reperfusión post-isquémica en la contractilidad, rigidez, edema y
T J Bixler1, J T Flaherty, T J Gardner
1Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Circulation
|September 1, 1978
Resumen
La administración de calcio después de un paro cardíaco mejora la función cardíaca y reduce la hinchazón sin causar más daño. Este hallazgo es crucial para comprender la protección de las células miocárdicas durante la terapia de reperfusión.
Área de la Ciencia:
- Cardiología Cardiología.
- Biología celular Biología celular.
- La bioquímica es la bioquímica.
Sus antecedentes:
- Se está investigando el papel del calcio en el daño celular miocárdico después de la isquemia y la reperfusión.
- El paro isquémico hipotérmico puede conducir a un deterioro de la función cardíaca y una lesión celular.
Objetivo del estudio:
- Investigar los efectos de la administración de calcio en la contractilidad y el daño miocárdico después de la parada isquémica hipotérmica y la reperfusión.
- Evaluar el potencial del calcio para mitigar los efectos negativos de las soluciones a base de citrato utilizadas en procedimientos cardíacos.
Principales métodos:
- Se utilizaron preparados cardíacos caninos isovolumicos perfundidos con sangre in situ (n=26).
- Los perros se dividieron en cuatro grupos: control normocalcémico, administración de cloruro de calcio (CaCl2), administración de citrato-fosfato-dextrosa (CPD) y administración combinada de CPD y CaCl2.
- Se evaluó la contractilidad ventricular izquierda, la rigidez miocárdica, la lesión celular / subcelular y el edema miocárdico después de la reperfusión.
Principales resultados:
- La administración de calcio (Grupo II) mejoró la contractilidad ventricular izquierda y aumentó la rigidez miocárdica sin causar daño celular adicional en comparación con los controles (Grupo I).
- La administración de citrato (CPD) (Grupo III) redujo la contractilidad y aumentó el edema miocárdico.
- La administración combinada de calcio y citrato (Grupo IV) revirtió la depresión de contractilidad inducida por citrato, minimizó el edema y aumentó la rigidez, sin daño morfológico adicional.
Conclusiones:
- El calcio administrado 15 minutos después de la reperfusión mejora la contractilidad cardíaca después de una parada isquémica hipotérmica.
- La administración de calcio puede contrarrestar los efectos negativos del citrato, ofreciendo beneficios potenciales en el cuidado cardíaco.
- El calcio parece ser un agente terapéutico seguro para mejorar la función cardíaca después de la isquemia sin exacerbar el daño miocárdico.
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