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Ligandos del TNF: ¿TALL-1 es un trímero o un grupo similar a un virus?

Eugene A Zhukovsky¹, Jie-Oh Lee, Michael Villegas

¹Xencor, Monrovia, California 91016, USA. ezhukovsky@xencor.com

|January 30, 2004

Resumen

El TALL-1 nativo, también conocido como factor de activación de células B (BAFF), es biológicamente activo como trímero, no como un complejo de 60 subunidades. Las estructuras de orden superior son el resultado de artefactos experimentales como las etiquetas de histidina.

Área de la Ciencia:

Inmunología Inmunología.
Biología Estructural Biología estructural.
La bioquímica es la bioquímica.

Sus antecedentes:

El factor de activación de las células B (BAFF), también conocido como TALL-1 o BlyS, es crucial para la supervivencia y maduración de las células B.
Estudios anteriores sugirieron que TALL-1 forma un complejo de 60 subunidades, propuesto como el oligómero biológicamente activo.
La organización estructural de TALL-1 tiene implicaciones para la comprensión de la regulación de las células B y las enfermedades autoinmunes.

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