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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Comparación de los resultados en pacientes con cáncer tratados dentro y fuera de los ensayos clínicos: marco
Jeffrey M Peppercorn1, Jane C Weeks, E Francis Cook
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Lancet (London, England)
|January 31, 2004
Resumen
La creencia de que los pacientes con cáncer en los ensayos clínicos tienen mejores resultados carece de pruebas suficientes. Se necesitan estudios más rigurosos para confirmar si un "efecto de prueba" realmente beneficia a los pacientes, más allá de mejorar futuros tratamientos.
Área de la Ciencia:
- Oncología Oncología Oncología.
- Metodología de la investigación clínica Metodología de la investigación clínica.
- La bioestadística es la bioestadística.
Sus antecedentes:
- Muchos oncólogos plantean la hipótesis de que los pacientes con cáncer en ensayos clínicos experimentan resultados superiores en comparación con los pacientes no incluidos en el ensayo.
- Este estudio examina críticamente la evidencia empírica que apoya la existencia de una
- El efecto del ensayo es el efecto del ensayo.
- en el cuidado del cáncer.
Objetivo del estudio:
- Evaluar la validez y la generalización de la evidencia que apoya una teoría.
- El efecto del ensayo es el efecto del ensayo.
- sobre los resultados de los pacientes en oncología.
Principales métodos:
- Se desarrolló un marco conceptual para comparar cohortes de pacientes de ensayo y no ensayo.
- Una búsqueda exhaustiva de la literatura identificó estudios que comparaban los resultados, con una evaluación crítica de sus metodologías.
- Se centró en los estudios que controlaban los factores de confusión y utilizaban grupos de control apropiados.
Principales resultados:
- Se analizaron 26 comparaciones de 24 artículos; 21 usaron diseños retrospectivos.
- 14 comparaciones sugirieron mejores resultados para los pacientes del ensayo, pero las limitaciones metodológicas fueron comunes.
- Solo 8 estudios restringieron los controles no experimentales a pacientes elegibles, y 3 mostraron mejores resultados en grupos de ensayo.
Conclusiones:
- Los datos robustos insuficientes actualmente apoyan la existencia de un
- El efecto del ensayo es el efecto del ensayo.
- mejorar los resultados para los pacientes con cáncer.
- Los pacientes aún deben ser alentados a unirse a ensayos clínicos por su papel establecido en el avance de futuros tratamientos contra el cáncer.
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