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Síntesis de vitamina D en la piel después de quemaduras
Gordon L Klein1, Tai C Chen, Michael F Holick
1Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu
Lancet (London, England)
|January 31, 2004
Resumen
Las quemaduras graves pueden provocar deficiencia de vitamina D en los niños, lo que afecta la salud ósea. Se recomienda la suplementación de vitamina D para abordar estas deficiencias después de la recuperación de quemaduras.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Dermatología Dermatología dermatología.
- La pediatría es la medicina de los niños.
Sus antecedentes:
- La lesión grave por quemaduras está relacionada con la deficiencia de vitamina D, el deterioro de la rotación ósea y los desequilibrios de calcio.
- La práctica clínica actual no proporciona rutinariamente suplementos de vitamina D ni controla la exposición al sol para los pacientes con quemaduras.
Objetivo del estudio:
- Para investigar la conversión del precursor de la vitamina D en la piel de los niños después de una lesión grave por quemaduras.
- Para evaluar los niveles séricos de 25-hidroxivitamina D en niños sobrevivientes de quemaduras.
Principales métodos:
- Análisis de muestras de biopsia cutánea para los precursores de vitamina D3.
- Medición de los efectos de la exposición a la luz ultravioleta B en la conversión del 7-dehidrocolesterol a la previtamina D3.
- Cuantificación de las concentraciones séricas de 25-hidroxivitamina D.
Principales resultados:
- Se observó una reducción significativa en la conversión de 7-dehidrocolesterol a previtamina D3 en niños, un promedio de 14 meses después de la quema.
- Se detectaron bajas concentraciones séricas de 25-hidroxivitamina D en la población del estudio.
Conclusiones:
- La conversión de los precursores de la vitamina D en la piel se ve afectada después de una lesión grave por quemaduras en niños.
- La deficiencia de vitamina D es un problema persistente en los sobrevivientes pediátricos de quemaduras.
- La suplementación rutinaria de vitamina D está indicada para los niños que se recuperan de lesiones graves por quemaduras.
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