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La 8-iso-prostaglandina F2alfa urinaria como marcador de riesgo en pacientes con enfermedad coronaria: un estudio
Edzard Schwedhelm1, Asja Bartling, Henrike Lenzen
1Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Germany. schwedhelm@uke.uni-hamburg.de
Circulation
|February 6, 2004
Resumen
El estrés oxidativo sistémico, indicado por niveles elevados de 8-iso-prostaglandina F2alfa (8-iso-PGF2alfa), está relacionado con la enfermedad coronaria (CHD). Este marcador, junto con la proteína C reactiva, predice de forma independiente el riesgo de ECC.
Área de la Ciencia:
- Investigaciones Cardiovasculares Investigación Cardiovascular Investigaciones Cardiovasculares
- Los biomarcadores también son biomarcadores.
- El estrés oxidativo es el estrés oxidativo.
Sus antecedentes:
- El estrés oxidativo juega un papel en la aterosclerosis y en los principales factores de riesgo de ECC como la diabetes, la hipertensión, la obesidad y el tabaquismo.
- Este estudio investigó la asociación entre los factores de riesgo de ECC y los niveles de estrés oxidativo sistémico.
Objetivo del estudio:
- Para probar la hipótesis de que los factores de riesgo de ECC se correlacionan con el aumento del estrés oxidativo sistémico.
- Identificar nuevos biomarcadores para la evaluación del riesgo de enfermedad coronaria.
Principales métodos:
- Un estudio de caso-control que involucró a 93 pacientes con ECC y 93 controles, emparejados por edad y sexo.
- Medición de la 8-iso-prostaglandina urinaria F2alfa (8-iso-PGF2alfa) y su metabolito mediante cromatografía de gases y espectrometría de masas en tándem.
- Análisis de parámetros clínicos que incluyen IMC, presión arterial, proteína C reactiva y colesterol HDL.
Principales resultados:
- Los pacientes con ECC presentaron un IMC, presión arterial sistólica, proteína C reactiva y niveles urinarios de 8-iso-PGF2alfa más altos en comparación con los controles.
- La excreción urinaria de 8-iso-PGF2alfa y sus metabolitos fue significativamente elevada en pacientes con ECC (P<0,001).
- En el análisis multivariado, los niveles elevados de 8-iso-PGF2alfa y proteína C reactiva fueron predictores independientes de ECC, con odds ratios de 30,8 y 7,2, respectivamente.
Conclusiones:
- La 8-iso-prostaglandina F2alpha (8-iso-PGF2alpha) es un marcador de riesgo sensible e independiente para la enfermedad coronaria (CHD).
- Los niveles urinarios de 8-iso-PGF2alfa se correlacionan con el número de factores de riesgo de ECC tradicionales.
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