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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

El componente del cuerpo citoplasmático TRIM5alpha restringe la infección por VIH-1 en monos del Viejo Mundo

Matthew Stremlau1, Christopher M Owens, Michel J Perron

  • 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|February 27, 2004
PubMed
Resumen

Los factores de las células huésped restringen la replicación del virus de la inmunodeficiencia humana tipo 1 (VIH-1) en primates. La proteína TRIM5alpha bloquea la entrada del VIH-1 en las células del mono, lo que explica la distribución viral específica de la especie y la resistencia innata.

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