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Updated: Jul 12, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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Published on: March 9, 2012

Las proteínas APPL vinculan Rab5 a la transducción de señales nucleares a través de un compartimento endosómico

Marta Miaczynska1, Savvas Christoforidis, Angelika Giner

  • 1Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

Cell
|March 16, 2004
PubMed
Resumen

Este estudio identifica una nueva vía de señalización que conecta los endosomas con el núcleo. Los efectores Rab5 APPL1 y APPL2 vinculan las señales extracelulares a la expresión génica y la proliferación celular.

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