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Disfunción endotelial y aumento del grosor de la intima-media arterial en niños con diabetes tipo 1
Mikko J Järvisalo1, Maria Raitakari, Jyri O Toikka
1Department of Clinical Physiology, University of Turku, Turku, Finland. mikko.jarvisalo@utu.fi
Circulation
|March 17, 2004
Resumen
Los niños con diabetes tipo 1 a menudo muestran deterioro de la función endotelial, indicado por la dilatación mediada por flujo reducido (FMD). Esta disfunción está relacionada con los primeros signos de aterosclerosis, específicamente el aumento del grosor íntima-media (IMT) de la arteria carótida.
Área de la Ciencia:
- Endocrinología Pediátrica Endocrinología pediátrica.
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- La diabetes mellitus es el tipo de diabetes.
Sus antecedentes:
- La disfunción endotelial está implicada en el desarrollo de la aterosclerosis en la diabetes tipo 1.
- La detección temprana de cambios vasculares en niños diabéticos es crucial.
Objetivo del estudio:
- Para investigar la función endotelial vascular en niños con diabetes tipo 1.
- Para determinar si la disfunción endotelial se correlaciona con cambios ateroscleróticos tempranos.
Principales métodos:
- Se utilizó ultrasonido no invasivo para evaluar la dilatación mediada por flujo de la arteria braquial (FMD) y el grosor íntima-media de la arteria carótida (IMT).
- Se estudiaron 75 niños: 45 con diabetes tipo 1 y 30 controles sanos.
Principales resultados:
- Los niños con diabetes tipo 1 presentaron una disminución significativa de la fiebre aftosa y un aumento de la TMI en comparación con los controles.
- La disfunción endotelial (fiebre aftosa baja) en niños diabéticos se asoció con un IMT carotídeo más alto y un colesterol LDL elevado.
- El análisis multivariado identificó la diabetes, la fiebre aftosa baja y el colesterol LDL alto como correlatos del aumento de la TMI.
Conclusiones:
- El deterioro de la fiebre aftosa es un hallazgo común en niños con diabetes tipo 1.
- La disfunción endotelial se asocia con un aumento de la TMI de la arteria carótida en esta población.
- Estos hallazgos sugieren una predisposición a la aterosclerosis temprana en niños con diabetes tipo 1 debido a la disfunción endotelial.
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