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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Inhibidores de la proteína quinasa: ideas sobre el diseño de fármacos desde la estructura

Martin E M Noble1, Jane A Endicott, Louise N Johnson

  • 1Laboratory of Molecular Biophysics, Department of Biochemistry, Rex Richards Building, University of Oxford, Oxford 3X2 3QU, UK.

Science (New York, N.Y.)
|March 20, 2004
PubMed
Resumen

Esta revisión cubre los inhibidores clínicos de la quinasa con los datos estructurales disponibles, destacando su papel en el diseño de fármacos y los mecanismos de inhibición para enfermedades como el cáncer y la inflamación.

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