Video Experimental Relacionado
Updated: Jul 19, 2026
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Sistemas de administración de drogas: entrando en la corriente principal.
Theresa M Allen1, Pieter R Cullis
1Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada. terry.allen@ualberta.ca
Science (New York, N.Y.)
|March 20, 2004
Resumen
Los sistemas de administración de fármacos (DDS) que utilizan nanopartículas mejoran las propiedades de los fármacos para la administración parenteral. Las formulaciones aprobadas de DDS y el interés en la administración de fármacos novedosos destacan su potencial terapéutico.
Área de la Ciencia:
- Ingeniería Biomédica Ingeniería Biomédica.
- Nanotecnología La nanotecnología es la nanotecnología.
- Farmacología Farmacología.
Sus antecedentes:
- Los sistemas de administración de fármacos de partículas (DDS, por sus siglas en inglés) se enfrentan a desafíos en su aplicación clínica.
- Las nanopartículas basadas en lípidos y polímeros ofrecen propiedades farmacológicas mejoradas para la administración parenteral.
- Varias formulaciones de DDS para medicamentos anticancerígenos y antifúngicos están clínicamente aprobadas.
Objetivo del estudio:
- Revisar los avances y aplicaciones de los sistemas de administración de fármacos.
- Para resaltar el potencial de DDS para nuevas terapias.
- Para discutir el uso de DDS en terapias dirigidas a los ligandos.
Principales métodos:
- Revisión de la literatura existente sobre los sistemas de administración de fármacos basados en nanopartículas.
- Análisis de las formulaciones clínicas DDS aprobadas.
- Exploración de aplicaciones emergentes en proteómica, genómica y terapéutica dirigida.
Principales resultados:
- Se han logrado avances significativos en la superación de los desafíos iniciales en el DDS de partículas.
- Las formulaciones aprobadas de DDS demuestran la viabilidad clínica de estos sistemas.
- Existe un creciente interés en la utilización de DDS para nuevos fármacos candidatos y entrega dirigida.
Conclusiones:
- Los sistemas de administración de fármacos, particularmente los basados en nanopartículas, han madurado significativamente.
- Los DDS son cruciales para mejorar la eficacia y seguridad de los medicamentos parenteral.
- Las futuras aplicaciones de DDS son prometedoras para la medicina personalizada y la terapéutica avanzada.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:18Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...
01:24Cellular Membranes and Drug Transport
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
01:26Oral Drug Delivery Systems: Continuous-Release Systems
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
01:18Transdermal Drug Delivery Systems
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...