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Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster
Published on: May 13, 2015
Bases genéticas de la variación natural en la inmunidad antibacteriana de D. melanogaster
Brian P Lazzaro1, Bonnielin K Sceurman, Andrew G Clark
1Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA. bl89@cornell.edu
Science (New York, N.Y.)
|March 20, 2004
Resumen
Las moscas de la fruta silvestre muestran diferencias significativas en la lucha contra las infecciones, vinculadas a las variaciones genéticas en sus genes del sistema inmunológico. Estas diferencias genéticas en el reconocimiento de patógenos y las vías de señalización impactan en la competencia inmune de la mosca.
Área de la Ciencia:
- * Genética evolutiva en la genética.
- * Inmunología.
- * La Drosophila melanogaster es objeto de investigación.
Sus antecedentes:
- * Se han identificado numerosos genes en el sistema inmunológico innato de Drosophila melanogaster.
- * Sin embargo, el impacto de las variaciones genéticas naturales en la función inmune en poblaciones silvestres sigue siendo en gran parte inexplorado.
Objetivo del estudio:
- * Para investigar el grado de variación en la competencia inmune entre las poblaciones de Drosophila melanogaster de origen silvestre.
- * Para determinar si los polimorfismos genéticos que ocurren naturalmente en los genes inmunes se correlacionan con las diferencias en el rendimiento inmune.
Principales métodos:
- * Se evaluó la capacidad de la Drosophila melanogaster de origen silvestre para suprimir la infección por el entomopatógeno Serratia marcescens.
- * Se analizaron polimorfismos de nucleótidos en 16 genes clave de inmunidad innata.
- * Interacciones epistáticas investigadas entre la señalización intracelular y los genes de péptidos antimicrobianos.
Principales resultados:
- * Se observó una variabilidad sustancial en la competencia inmune entre la Drosophila melanogaster silvestre.
- * Se encontraron asociaciones significativas entre la variación de la competencia inmune y los polimorfismos de nucleótidos en 16 genes de inmunidad innata, particularmente aquellos involucrados en el reconocimiento de patógenos y la señalización intracelular.
- * Se detectó una epistasis significativa entre la señalización intracelular y los genes de péptidos antimicrobianos.
Conclusiones:
- * Las variaciones genéticas que ocurren naturalmente en los genes de inmunidad innata de Drosophila melanogaster contribuyen a las diferencias en la competencia inmune.
- * Los polimorfismos en el reconocimiento de patógenos y los genes de señalización intracelular juegan un papel crucial en la conducción de la variación inmune.
- * Las interacciones epistáticas entre diferentes categorías de genes inmunes influyen en la inmunocompetencia general en las poblaciones de moscas silvestres.
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