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Videos de Conceptos Relacionados

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

El cáncer de páncreas es un cáncer de páncreas.

Donghui Li1, Keping Xie, Robert Wolff

  • 1Department of Gastrointestinal Medical Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, TX 77030, USA.

Lancet (London, England)
|March 31, 2004
PubMed
Resumen

El cáncer de páncreas tiene un mal pronóstico, con opciones de tratamiento limitadas y alta mortalidad. Los avances en la comprensión de su biología molecular ofrecen la esperanza de desarrollar terapias más efectivas.

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Área de la Ciencia:

  • Oncología Oncología.
  • Biología Molecular Biología Molecular
  • Investigación del cáncer Investigación del cáncer.

Sus antecedentes:

  • El cáncer de páncreas es un desafío significativo para la salud con malos resultados.
  • Los tratamientos convencionales son en gran medida ineficaces, y la mayoría de los pacientes desarrollan metástasis fatales.
  • Los principales factores de riesgo incluyen el tabaquismo, la edad y las predisposiciones genéticas, pero las causas primarias siguen sin estar claras.

Objetivo del estudio:

  • Revisar la comprensión actual de la patogénesis del cáncer de páncreas.
  • Para discutir las limitaciones de los tratamientos existentes.
  • Para resaltar nuevas estrategias terapéuticas prometedoras.

Principales métodos:

  • Revisión de los avances de la biología molecular en la comprensión del cáncer de páncreas.
  • Análisis de las modalidades actuales de tratamiento y sus beneficios paliativos.
  • Exploración de los enfoques terapéuticos emergentes.

Principales resultados:

  • La patogénesis del cáncer de páncreas implica mutaciones en el oncógeno K-ras y genes supresores de tumores inactivados.
  • Los factores de crecimiento juegan un papel crítico en la progresión de la enfermedad.
  • Los tratamientos actuales ofrecen beneficios de supervivencia limitados, con una supervivencia a 5 años de alrededor del 20% para los casos resecables.

Conclusiones:

  • El cáncer de páncreas sigue siendo resistente a las terapias actuales, lo que requiere nuevos enfoques.
  • Se están explorando métodos de investigación como la quimiorradiación preoperatoria y el uso ampliado de gemcitabina.
  • Las estrategias terapéuticas dirigidas a los fundamentos moleculares del cáncer de páncreas son las más prometedoras para mejorar los resultados de los pacientes.