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El virus de Epstein-Barr en la esclerosis múltiple pediátrica
Suad Alotaibi1, Julia Kennedy, Raymond Tellier
1Department of Pediatrics(Neurology), Al-Sabah Hospital, Shuwaikh, Kuwait.
JAMA
|April 22, 2004
Resumen
Los pacientes pediátricos con esclerosis múltiple (EM) muestran una mayor seropositividad para la infección por el virus de Epstein-Barr (EBV) en comparación con los niños sanos. Esto sugiere un vínculo potencial entre el EBV y el desarrollo de EM en individuos más jóvenes.
Área de la Ciencia:
- Virología Virología.
- Neurología Neurología.
- Inmunología Inmunología.
Sus antecedentes:
- El virus de Epstein-Barr (EBV) es un presunto contribuyente a la patogénesis de la esclerosis múltiple (EM).
- Existe una investigación limitada sobre las asociaciones virales en la EM pediátrica.
Objetivo del estudio:
- Investigar la seropositividad para el EBV y otros virus comunes en niños con EM en comparación con controles sanos.
- Explorar los posibles factores virológicos en la EM pediátrica.
Principales métodos:
- Un estudio de caso-control en el que participaron 30 pacientes pediátricos con EM y 143 controles (90 de urgencias, 53 sanos).
- Se analizaron muestras de suero para detectar anticuerpos IgG contra el EBV, el citomegalovirus, el parvovirus B19, el virus del herpes simple y la varicela zóster.
- Los controles emparejados se basaron en el año de nacimiento.
Principales resultados:
- El 83% de los pacientes pediátricos con EM tenían evidencia serológica de infección remota por EBV frente al 42% de los controles (P<.001).
- Los pacientes pediátricos con EM tenían menos probabilidades de haber estado expuestos al virus del herpes simple (P=.003).
- No hay diferencia significativa en la seropositividad para el citomegalovirus, el parvovirus B19 o la varicela zoster.
Conclusiones:
- Los hallazgos sugieren una asociación significativa entre la infección por el virus de Epstein-Barr y la EM pediátrica.
- El EBV puede desempeñar un papel en el desarrollo de la EM en niños.
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