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La osteoprotegerina es un factor de riesgo para la aterosclerosis progresiva y la enfermedad cardiovascular
Stefan Kiechl1, Georg Schett, Gregor Wenning
1Department of Neurology, University Clinic, Anichstrasse 35, A-6020 Innsbruck, Austria. Stefan.Kiechl@uibk.ac.at
Circulation
|May 1, 2004
Resumen
La osteoprotegerina es un factor de riesgo independiente significativo para la enfermedad cardiovascular y la progresión de la aterosclerosis. Los niveles más altos predicen un mayor riesgo de enfermedad vascular y mortalidad en la población general.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Los biomarcadores también son biomarcadores.
- La aterosclerosis es la aterosclerosis.
Sus antecedentes:
- La osteoprotegerina (OPG) es un nuevo miembro de la superfamilia de receptores del factor de necrosis tumoral.
- OPG actúa como un receptor señuelo para el receptor activador del ligando del factor nuclear-kappaB.
- Investigaciones emergentes sugieren el papel de OPG en la aterogénesis, lo que requiere validación epidemiológica.
Objetivo del estudio:
- Investigar la asociación epidemiológica entre los niveles de GPO y la aterosclerosis.
- Determinar si la GPO es un factor de riesgo independiente para la enfermedad cardiovascular (ECV) y la mortalidad vascular.
Principales métodos:
- Estudio Bruneck prospectivo y basado en la población (1990-2000).
- Evaluación de la aterosclerosis de la arteria carótida (gravedad, inicio, progresión).
- Medición de los niveles séricos de GPO en el inicio y el seguimiento; registro de incidentes de ECV y mortalidad vascular.
Principales resultados:
- OPG sérico correlacionado con factores de riesgo vascular: edad, diabetes, inflamación, infección y tabaquismo.
- Los niveles de OPG se asociaron significativamente con la gravedad de la aterosclerosis carotídea y la progresión a los 10 años.
- El alto OPG fue un predictor independiente de la EVC incidente (RR 2.2) y la mortalidad vascular (RR 3.1).
Conclusiones:
- La osteoprotegerina es un factor de riesgo independiente para la progresión de la aterosclerosis.
- Los niveles elevados de OPG predicen enfermedades cardiovasculares incidentes y mortalidad vascular.
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