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La participación de la corteza cingulada anterior en la memoria de miedo contextual remota
Paul W Frankland1, Bruno Bontempi, Lynn E Talton
1Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095-1761, USA.
Science (New York, N.Y.)
|May 8, 2004
Resumen
La corteza cingulada anterior es crucial para almacenar recuerdos de miedo a largo plazo. Su actividad es necesaria para la recuperación de la memoria remota, pero no para la memoria reciente.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación de la memoria Investigación de la memoria.
- La neurociencia de sistemas es la neurociencia de sistemas.
Sus antecedentes:
- Los mecanismos del procesamiento inicial de la memoria están bien estudiados.
- Los procesos subyacentes al almacenamiento de memoria permanente siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para investigar el papel de la corteza cingulada anterior en el almacenamiento remoto de la memoria.
- Identificar sustratos neuronales críticos para la memoria del miedo contextual a largo plazo.
Principales métodos:
- El análisis neuroanatómico.
- Manipulación farmacológica manipulación farmacológica.
- Estudios genéticos con las mutaciones alfa-CaMKII.
- Imágenes in vivo de genes dependientes de la actividad.
- Inactivación reversible de las regiones cerebrales.
Principales resultados:
- La corteza cingulada anterior se activa durante el recuerdo remoto de la memoria.
- Una mutación alfa-CaMKII nula afecta la activación de la corteza cingulada anterior y la memoria remota.
- La inactivación reversible de la corteza cingulada anterior interrumpe la memoria remota pero no la memoria reciente.
Conclusiones:
- La corteza cingulada anterior es esencial para el almacenamiento y la recuperación de recuerdos de miedo contextuales remotos.
- Las vías moleculares específicas, como las que involucran a alfa-CaMKII, son críticas para la consolidación de la memoria a largo plazo en esta región.
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