Aumento del número de adipocitos como base para el crecimiento de depósitos perirenales en ratas adultas
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Science (New York, N.Y.)
|September 29, 1978
Resumen
El tejido adiposo en ratas machos crece al aumentar el número de células grasas en el área perirenal y el tamaño de las células grasas en el área epididimal entre los 6 y los 18 meses de edad.
Área de la Ciencia:
- Biología del tejido adiposo Biología del tejido adiposo
- Investigación sobre el envejecimiento de la investigación.
- Modelos de ratas Modelos de ratas
Sus antecedentes:
- El número de adipocitos se considera tradicionalmente constante en la vida adulta.
- Comprender los depósitos de tejido adiposo es crucial para la salud metabólica.
Objetivo del estudio:
- Para investigar los cambios relacionados con la edad en los depósitos adiposos perirenales y epididimales en ratas machos Fischer 344.
- Determinar los mecanismos que impulsan la expansión de la masa del tejido adiposo durante el envejecimiento.
Principales métodos:
- Análisis de la masa de tejido adiposo en ratas Fischer 344 de diferentes edades (6-18 meses).
- Examen histológico para cuantificar el número y el tamaño de los adipocitos.
Principales resultados:
- La masa de depósito adiposo perirenal aumentó significativamente con la edad.
- Este aumento se atribuyó a un mayor número de adipocitos, desafiando la noción de un número de adipocitos constante.
- La masa del depósito adiposo epidídimo también aumentó, pero únicamente debido a la hipertrofia (agrandamiento) de los adipocitos.
Conclusiones:
- La proliferación de adipocitos contribuye a la expansión del tejido adiposo en depósitos específicos durante el envejecimiento.
- El envejecimiento implica mecanismos distintos de crecimiento del tejido adiposo en diferentes ubicaciones anatómicas.
- Los hallazgos proporcionan nuevos conocimientos sobre la naturaleza dinámica del tejido adiposo durante el proceso de envejecimiento.
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