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Published on: October 23, 2020
La relaxina es un factor de riesgo independiente que predice la muerte en pacientes masculinos con enfermedad renal
Berthold Hocher1, Reinhard Ziebig, Rolfdieter Krause
1Humboldt University of Berlin, University Hospital Charité, Center for Cardiovascular Research, Department of Nephrology, Charité, Berlin, Germany. berthold.hocher@charite.de
Circulation
|May 12, 2004
Resumen
Los altos niveles de relaxina predicen la muerte en pacientes masculinos con enfermedad renal en etapa terminal (ESKD) sometidos a hemodiálisis. Este hallazgo destaca la relaxina como un factor de riesgo significativo para la mortalidad en esta población.
Área de la Ciencia:
- Nefrología Nefrología.
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Endocrinología Endocrinología.
Sus antecedentes:
- Los pacientes con enfermedad renal en etapa terminal (ESKD) experimentan una esperanza de vida reducida, principalmente debido a enfermedades cardiovasculares.
- La relaxina ha sido identificada como un factor potencial en el desarrollo de enfermedades cardiovasculares.
Objetivo del estudio:
- Investigar el impacto de la relaxina en la mortalidad en pacientes con ESKD.
- Para determinar si la relaxina es un factor de riesgo independiente para la muerte en pacientes con ESKD sometidos a hemodiálisis.
Principales métodos:
- Una cohorte de 245 pacientes en hemodiálisis a largo plazo fue seguida para la mortalidad durante 1140 días.
- Las concentraciones séricas de relaxina y otros biomarcadores se midieron al inicio del estudio.
- El análisis de supervivencia se realizó utilizando los métodos de regresión de Kaplan-Meier y Cox.
Principales resultados:
- Las elevadas concentraciones séricas de relaxina predijeron la muerte por todas las causas y la muerte cardiovascular en pacientes masculinos.
- El riesgo relativo de muerte por cualquier causa en hombres con relaxina alta fue de 2,63 (P=0,005).
- No se encontró una asociación significativa entre los niveles de relaxina y la muerte en pacientes femeninas.
Conclusiones:
- La relaxina es un factor de riesgo independiente para predecir la muerte en pacientes masculinos con ESKD en hemodiálisis crónica.
- Los hallazgos sugieren un papel específico por sexo de la relaxina en la mortalidad por ESKD.
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