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Invasion of Human Cells by a Bacterial Pathogen
Published on: March 21, 2011
La fibrina soluble es el principal mediador de la adhesión de Staphylococcus aureus a las plaquetas
Silke Niemann1, Nicola Spehr, Hugo Van Aken
1Department of Anaesthesiology and Intensive Care, University Hospital Muenster, Muenster, Germany.
Circulation
|June 16, 2004
Resumen
Las plaquetas se unen al Staphylococcus aureus principalmente a través de fibrina soluble y contenido de gránulos alfa liberados como la trombospondina-1, no el fibrinógeno. La activación plaquetaria es crucial para esta asociación, que es clave en la endocarditis infecciosa.
Área de la Ciencia:
- Hematología Hematología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Microbiología Microbiología.
Sus antecedentes:
- La endocarditis infecciosa por Staphylococcus aureus (IE) presenta una morbilidad y mortalidad significativas.
- Las plaquetas tienen un papel complejo en la IE, actuando como células adhesivas e inflamatorias.
- Los mecanismos de la asociación entre Staphylococcus aureus y las plaquetas no se comprenden completamente.
Objetivo del estudio:
- Para aclarar los factores y receptores específicos que median la asociación de Staphylococcus aureus y plaquetas.
- Para investigar el papel de la activación plaquetaria y el contenido de gránulos en la unión bacteriana.
Principales métodos:
- Utilizó ratones knockout y plaquetas derivadas de pacientes con deficiencias específicas.
- Se han probado varios activadores plaquetarios (trombina, ADP) y proteínas (fibrinógeno, fibrina, trombospondina-1).
- Se ha evaluado la unión de Staphylococcus aureus a las plaquetas activadas y no activadas.
Principales resultados:
- La activación de la trombina aumentó dramáticamente la unión de Staphylococcus aureus a las plaquetas.
- CD36, GPIIb/IIIa y P-selectina no fueron identificados como receptores.
- Los contenidos de gránulos alfa, particularmente la trombospondina-1, y la fibrina soluble fueron esenciales para la asociación.
Conclusiones:
- La fibrina soluble, no el fibrinógeno, es el principal mediador de la asociación Staphylococcus aureus-plaquetas.
- La activación plaquetaria y la liberación de gránulos alfa, incluida la trombospondina-1, son necesarias para esta unión.
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