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Updated: Jul 5, 2026

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System
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Las cinasas dependientes de la ciclina regulan la función antiproliferativa de Smads

Isao Matsuura1, Natalia G Denissova, Guannan Wang

  • 1Center for Advanced Biotechnology and Medicine,Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

Nature
|July 9, 2004
PubMed
Resumen

Las cinasas dependientes de ciclina (CDKs) fosforilan Smad3, inhibiendo su actividad supresora del crecimiento. Esta inhibición de Smad3 mediada por CDK puede impulsar el desarrollo de cáncer y la resistencia al factor de crecimiento transformador-beta (TGF-beta).

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