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Enfermedad de Huntington: nuevos caminos hacia la patogénesis.
1Department of Psychiatry, 618 Ross Research Building, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Cell
|July 10, 2004
Resumen
La enfermedad de Huntington implica una expansión repetida de CAG en el gen de la huntingtina, interrumpiendo el transporte axonal y la entrega del factor neurotrófico. Este descubrimiento ofrece nuevos conocimientos sobre las vías neurodegenerativas y posibles objetivos terapéuticos para esta condición.
Área de la Ciencia:
- Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos Trastornos neurodegenerativos
- Genética La genética.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La enfermedad de Huntington (HD) es un trastorno neurodegenerativo autosómico dominante.
- Se caracteriza por la expansión de una repetición CAG dentro del gen huntingtina, lo que lleva a una expansión de poliglutamina en la proteína huntingtina.
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