La memoria cardíaca evoluciona con la edad en asociación con el desarrollo de la corriente exterior transitoria
Alexei N Plotnikov1, Eugene A Sosunov, Kornelis W Patberg
1Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Circulation
|July 21, 2004
Resumen
La memoria cardíaca (CM) se desarrolla con la edad debido a la maduración de la corriente externa transitoria insensible al calcio (I(to)). Este proceso implica cambios en la muesca del potencial de acción epicárdica y la expresión génica relacionada, que influyen en la capacidad de remodelación eléctrica del corazón.
Área de la Ciencia:
- Cardiología Cardiología.
- Electrofisiología y electrofisiología.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- La corriente externa transitoria insensible al calcio (I(to)) juega un papel crucial en la memoria cardíaca (CM).
- La memoria cardíaca refleja la capacidad de remodelación electrofisiológica del corazón.
- El estudio investiga la maduración del desarrollo de I (((to) como un conductor de la evolución de CM.
Objetivo del estudio:
- Para probar la hipótesis de que la evolución de la memoria cardíaca es impulsada por la maduración del desarrollo de I(a).
- Para entender los cambios dependientes de la edad en la remodelación electrofisiológica en el corazón.
Principales métodos:
- El ritmo cardíaco se utilizó para inducir la CM en perros de diferentes edades (1 día a adulto).
- Se midió el desplazamiento del vector de onda T (TVD) para cuantificar CM.
- Los estudios de microelectrodos evaluaron las características de la muesca del potencial de acción epicárdica.
- La expresión del ARNm KChIP2 y Kv4.3 se cuantificó utilizando RT-PCR.
Principales resultados:
- La TVD fue significativamente mayor en adultos que en neonatos y aumentó con la edad, alcanzando los niveles de adultos en aproximadamente 200 días.
- La muesca del potencial de acción epicárdica, ausente en los neonatos, se hizo evidente y se profundizó con la edad.
- Se observó una correlación positiva entre la magnitud de la muesca y el TVD.
- Los niveles de KChIP2 y Kv4.3 de ARNm aumentaron con la edad, reflejando el desarrollo de la CM.
Conclusiones:
- La inducibilidad de la memoria cardíaca aumenta con la edad.
- Este aumento dependiente de la edad está asociado con la evolución de la muesca del potencial de acción epicárdico y la expresión del ARNm KChIP2/Kv4.3.
- La capacidad del corazón para la remodelación electrofisiológica y la memoria durante el desarrollo depende en parte de la maduración de los determinantes.
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