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El ácido 20-hidroxyeicosatetraenoico urinario está asociado con la disfunción endotelial en humanos
Natalie C Ward1, Jennifer Rivera, Jonathan Hodgson
1School of Medicine & Pharmacology, University of Western Australia & West Australian Institute of Medical Research, Perth, Australia.
Circulation
|July 21, 2004
Resumen
La excreción urinaria de ácido 20-hidroxyeicosatetraenoico (20-HETE) está relacionada con el deterioro de la función endotelial vascular en humanos. Este estudio revela una asociación inversa significativa entre los niveles de 20-HETE y la vasodilatación dependiente del endotelio.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Hipertensión La patogénesis de la patogénesis de la hipertensión
- Endocrinología Endocrinología.
Sus antecedentes:
- El ácido 20-hidroxyeicosatetraenoico (20-HETE) es un metabolito vasoconstrictor del ácido araquidónico.
- El 20-HETE elevado puede contribuir al desarrollo de la hipertensión.
- Existen datos humanos limitados sobre el papel de 20-HETE en la fisiopatología vascular.
Objetivo del estudio:
- Para investigar la relación entre la excreción urinaria de 20-HETE y la presión arterial en humanos.
- Para determinar la asociación entre los niveles de 20-HETE y la función endotelial vascular in vivo.
- Explorar las posibles diferencias específicas de género en estas relaciones.
Principales métodos:
- La excreción urinaria de 20-HETE se cuantificó utilizando cromatografía de gases / espectrometría de masas en 66 sujetos.
- La vasodilatación dependiente del endotelio se evaluó a través de la dilatación mediada por flujo de la arteria braquial.
- Se emplearon análisis estadísticos, incluyendo regresión múltiple, para evaluar las asociaciones.
Principales resultados:
- No se encontró ninguna diferencia significativa en la excreción de 20-HETE entre sujetos hipertensos y normotensos.
- 20-HETE urinario mostró una correlación positiva con el índice de masa corporal y la excreción de sodio.
- Se observó una relación inversa significativa entre la excreción de 20-HETE y la vasodilatación dependiente del endotelio (P=0,006).
- El 20-HETE siguió siendo un predictor independiente de la vasodilatación, particularmente en las mujeres, donde una mayor excreción se correlacionó con una presión arterial elevada.
Conclusiones:
- Este estudio proporciona la primera evidencia que vincula la excreción de 20-HETE con la función vascular in vivo en humanos.
- Los hallazgos sugieren un papel potencial para 20-HETE en la modulación de la fisiología vascular humana.
- El efecto inhibidor del óxido nítrico sobre la omega-hidroxilasa puede influir en el impacto vascular de 20-HETE.
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