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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
La fisiopatología de la muerte celular mitocondrial
Douglas R Green1, Guido Kroemer
1Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. doug@liai.org
Science (New York, N.Y.)
|August 3, 2004
Resumen
La permeabilización de la membrana externa mitocondrial (MOMP) desencadena la apoptosis mediante la liberación de factores de muerte. Comprender la regulación MOMP es clave para el desarrollo de terapias contra el cáncer y otras enfermedades.
Área de la Ciencia:
- Biología celular Biología celular.
- La bioquímica es la bioquímica.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La activación de la caspasa, central para la apoptosis, está estrictamente regulada por la permeabilización de la membrana externa mitocondrial (MOMP).
- La MOMP es inducida por varias señales pro-apoptóticas que convergen en las mitocondrias.
- La familia de proteínas Bcl-2, los lípidos y los reguladores metabólicos son actores clave en la ejecución de la MOMP.
Objetivo del estudio:
- Para discutir las reglas generales que rigen la fisiopatología de la MOMP.
- Para explorar cuestiones controvertidas en la regulación MOMP.
- Para resaltar las estrategias terapéuticas dirigidas a la MOMP.
Principales métodos:
- Revisión de la literatura existente sobre la apoptosis y la MOMP.
- Análisis de los mecanismos moleculares que regulan el MOMP.
- Discusión de los estímulos patológicos y las intervenciones terapéuticas relacionadas con la MOMP.
Principales resultados:
- La MOMP conduce a la muerte celular a través de la activación de la caspasa y/o la falla metabólica.
- La desregulación de la MOMP está implicada en la muerte celular patológica y el cáncer.
- La orientación a la MOMP ofrece un potencial terapéutico para diversas enfermedades.
Conclusiones:
- La MOMP es un evento crítico y letal en la apoptosis.
- La regulación precisa de la MOMP es esencial para la homeostasis celular.
- La modulación de la MOMP es prometedora para el tratamiento del cáncer y otras afecciones.
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