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El patrón de fibra muscular es independiente del linaje celular en el desarrollo postnatal de roedores
1Department of Pharmacology, Stanford University School of Medicine, California 94305-5332.
Cell
|February 21, 1992
Resumen
Los patrones de las fibras musculares no están determinados por el linaje de los mioblastos durante el desarrollo. En cambio, las señales externas guían el desarrollo de las fibras musculares, anulando cualquier programación genética intrínseca de los mioblastos.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
- Fisiología muscular La fisiología muscular.
Sus antecedentes:
- Las fibras musculares exhiben patrones distintos de contracción rápida y lenta en el desarrollo de las extremidades.
- Los estudios in vitro sugieren que los linajes específicos de los mioblastos podrían dictar el tipo y el patrón de la fibra muscular.
Objetivo del estudio:
- Investigar si los linajes distintos de mioblastos son responsables de establecer patrones de fibra muscular in vivo.
- Para determinar si las señales extrínsecas influyen en el destino del mioblasto y el patrón de las fibras musculares.
Principales métodos:
- Utilizó el etiquetado retroviral para etiquetar genéticamente y rastrear clones de mioblastos individuales in vivo.
- Analizó la contribución de los clones de mioblastos etiquetados a diferentes tipos de fibras musculares dentro del desarrollo de las extremidades.
Principales resultados:
- Los clones de mioblastos, ya sea etiquetados in situ o después de cultivo y trasplante in vitro, contribuyeron a la progenie de todos los tipos de fibras musculares encontrados.
- Se demostró que la progenie de los mioblastos no se limita a formar tipos específicos de fibra en función de su origen.
Conclusiones:
- El patrón de fibra muscular en el desarrollo posnatal no está dictado por el linaje de los mioblastos.
- Las señales ambientales extrínsecas juegan un papel crucial para anular la programación intrínseca del mioblasto y determinar el tipo y el patrón de la fibra muscular.
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