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La síntesis de lipoxina dependiente de la ciclooxigenasa-2 desencadenada por la aspirina modula el tono vascular
Pierre-Yves von der Weid1, Morley D Hollenberg, Stefano Fiorucci
1Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada.
Circulation
|August 25, 2004
Resumen
La lipoxina A ((4) desencadenada por la aspirina influye en el tono vascular y la presión arterial. La inhibición de la síntesis de lipoxina amplifica los efectos presores de la aspirina, destacando el papel de las lipoxinas en la regulación cardiovascular.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Biología de la inflamación Biología de la inflamación.
- Farmacología Farmacología.
Sus antecedentes:
- La aspirina desencadena la producción de 15-R-epilipoxina A4 (ATL), conocida por sus efectos antiinflamatorios y protectores gástricos.
- El impacto de la ATL en el tono vascular y su papel en los efectos cardiovasculares de la aspirina siguen siendo en gran parte inexplorados.
Objetivo del estudio:
- Investigar la contribución de la ATL a los cambios en el tono vascular inducidos por la aspirina.
- Examinar el papel del óxido nítrico (NO) en la mediación de los efectos vasculares de la aspirina y la ATL.
Principales métodos:
- Cambios evaluados en la presión arterial (BP) después de la administración de aspirina in vivo.
- Utilizó inhibidores selectivos de la ciclooxigenasa-2 y 5-lipoxigenasa, un antagonista del receptor de lipoxina (Boc2) y inmunodepleción de neutrófilos para modular la síntesis de ATL.
- Efectos vasorelaxantes confirmados de la lipoxina A ((4) en segmentos aislados de la arteria aórtica y mesentérica de ratas, evaluando la dependencia del endotelio.
Principales resultados:
- La lipoxina intravenosa A(4) causó una reducción transitoria en la presión arterial.
- La aspirina aumentó el ATL sérico y la presión arterial; la inhibición de la síntesis de ATL aumentó significativamente el aumento de la presión arterial inducido por la aspirina.
- La lipoxina A ((4) indujo una vasorelaxación dependiente del endotelio en arterias aisladas.
Conclusiones:
- La síntesis de lipoxina desencadenada por aspirina modula el tono vascular y la presión arterial sistémica.
- Las lipoxinas pueden desempeñar un papel en la regulación del flujo sanguíneo regional durante las respuestas inflamatorias.
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