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La acidosis intracelular aumenta la excitabilidad del músculo de trabajo

Thomas H Pedersen¹, Ole B Nielsen, Graham D Lamb

¹Department of Physiology, University of Aarhus, DK-8000, Denmark.

Science (New York, N.Y.)

|August 25, 2004

Resumen

La acidosis intracelular en los músculos esqueléticos preserva la excitabilidad durante la fatiga al disminuir la permeabilidad del cloruro. Esto permite que los potenciales de acción se propaguen, destacando las funciones protectoras de los canales de acidosis y cloruro en la función muscular.

Área de la Ciencia:

Fisiología muscular La fisiología muscular.
Electrofisiología celular electrofisiología celular.
La función del músculo esquelético

Sus antecedentes:

La acidificación intracelular está relacionada con la fatiga del músculo esquelético.
Los músculos que trabajan experimentan una despolarización, lo que puede afectar la excitabilidad.
El papel de la acidosis en la preservación de la excitabilidad muscular durante la despolarización no se entiende completamente.

Objetivo del estudio:

Investigar el papel protector de la acidosis intracelular en el mantenimiento de la excitabilidad del músculo esquelético durante la despolarización.
Aclarar los mecanismos subyacentes a la preservación de la excitabilidad muscular inducida por la acidosis.

Principales métodos:

Investigó la relación entre el pH intracelular, la despolarización muscular y la excitabilidad.
Se evaluó el papel de la permeabilidad del cloruro en la propagación del potencial de acción dentro de las fibras musculares.

Principales resultados:

Se demostró que la acidosis intracelular preserva la excitabilidad muscular durante la despolarización.
Se demostró que la disminución de la permeabilidad del cloruro media este efecto protector.
Se confirmó que los potenciales de acción aún pueden propagarse a lo largo del sistema de túbulos T a pesar de la despolarización.

Conclusiones:

La acidosis intracelular confiere un efecto protector sobre la función del músculo esquelético durante la fatiga.
Los canales iónicos de cloruro están implicados como actores clave en la regulación de la excitabilidad muscular en condiciones ácidas.
Los hallazgos desafían la visión únicamente perjudicial de la acidosis muscular, revelando sus beneficios funcionales.

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