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Isquemia del tejido sensorial: ¿otra nueva función para los receptores de capsaicina?
1Department of Anesthesiology, H187, Pennsylvania State University College of Medicine, and the Milton S. Hershey Medical Center, 500 University Dr, Hershey, PA 17033-0850, USA. hpan@psu.edu
Circulation
|September 15, 2004
Resumen
El receptor vanilloide-1 (VR1) en los nervios sensoriales cardíacos detecta la isquemia del miocardio. El bloqueo de VR1 con antagonistas reduce significativamente la activación nerviosa durante la isquemia y la aplicación de bradicinina.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- La neurociencia es la neurociencia.
- Señalización de la señal de dolor.
Sus antecedentes:
- El dolor en el pecho es un síntoma clave de la isquemia miocárdica, pero sus vías de señalización no están claras.
- El receptor vanilloide-1 (VR1) es un canal catiónico en las neuronas nociceptivas, que se encuentra en las terminaciones nerviosas sensoriales cardíacas.
- Se investigó el papel de VR1 en la activación de los nervios cardíacos durante la isquemia.
Objetivo del estudio:
- Determinar el papel del receptor vanilloide-1 (VR1) en la activación de los nervios aferentes espinales cardíacos durante la isquemia miocárdica.
Principales métodos:
- Actividad registrada de una sola unidad de aferentes cardíacos en hurones anestesiados.
- Isquemia miocárdica inducida regional y bradicinina aplicada.
- Se administraron antagonistas de VR1 (iodoresiniferatoxina) y bloqueadores (rueno de rutenio) para evaluar sus efectos sobre la actividad nerviosa aferente.
Principales resultados:
- Los aferentes cardíacos respondieron a la isquemia miocárdica y a la bradicinina.
- La iodoresiniferatoxina atenuó significativamente la respuesta aferente tanto a la isquemia como a la bradicinina.
- El rojo de rutenio demostró efectos inhibidores similares en las respuestas aferentes.
Conclusiones:
- Proporciona la primera evidencia funcional de que VR1 media la estimulación isquémica de los nervios aferentes espinales cardíacos.
- Sugiere que VR1 actúa como un sensor molecular para la isquemia tisular en los nervios sensoriales cardíacos, activando los nociceptores cardíacos.
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