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Performing Custom MicroRNA Microarray Experiments
Published on: October 28, 2011
Las funciones de los microARN animales
1Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA (e-mail: vra@dartmouth.edu)
Nature
|September 17, 2004
Resumen
Los microARN (miRNA) son pequeñas moléculas de ARN que regulan la expresión génica en diversos animales. Estas moléculas conservadas juegan un papel crucial en el desarrollo y las funciones celulares, lo que indica un impacto regulatorio más amplio de lo que se entendía anteriormente.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Genética La genética.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- Los microARN (miRNA) son pequeñas moléculas de ARN involucradas en la regulación genética post-transcripcional.
- Cientos de genes de miRNA han sido identificados en varias especies animales.
- Muchos miARN animales exhiben conservación filogenética, lo que sugiere funciones biológicas fundamentales.
Objetivo del estudio:
- Para resumir la comprensión actual de los genes de microARN y sus funciones en los animales.
- Para resaltar las funciones en expansión de los miRNA en diversos procesos biológicos.
- Para subrayar la influencia reguladora generalizada de los miRNA animales.
Principales métodos:
- Revisión de la literatura y síntesis de la investigación existente sobre los microARN animales.
- Análisis de los patrones de conservación filogenética de los genes de miRNA.
- Compilación de las funciones conocidas de miRNA en diferentes taxones animales.
Principales resultados:
- Identificación de numerosos genes de miRNA conservados en diversas filas animales.
- Papel documentado de los miARN en procesos clave del desarrollo incluyendo el tiempo, la muerte celular, la proliferación, la hematopoyesis y el patrón neural.
- La creciente evidencia sugiere un papel más extenso e impactante para los miRNA en la biología animal de lo que se reconoció inicialmente.
Conclusiones:
- Los microARN animales son reguladores críticos de la expresión génica con funciones biológicas muy extendidas.
- Es probable que el número y el impacto regulatorio de los miARN animales sean mayores de lo que se apreciaba anteriormente.
- La investigación adicional sobre las vías de miRNA continuará revelando su importancia fundamental en el desarrollo y la fisiología de los animales.
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