Video Experimental Relacionado
Updated: Jul 18, 2026
07:54
Immunostaining to Visualize Murine Enteric Nervous System Development
Published on: April 29, 2015
La definición de un vínculo con el asma en ratones con deficiencia congénita de eosinófilos
James J Lee1, Dawn Dimina, MiMi P Macias
1Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. jjlee@mayo.edu
Science (New York, N.Y.)
|September 18, 2004
Resumen
La investigación del asma avanzó con un nuevo modelo de ratón con deficiencia de eosinófilos. Estos ratones revelaron que los eosinófilos son cruciales para la acumulación de moco y la hipersensibilidad de las vías respiratorias en el asma.
Área de la Ciencia:
- Inmunología Inmunología.
- Medicina Pulmonar La medicina pulmonar es el tratamiento de las enfermedades pulmonares.
- Genética La genética.
Sus antecedentes:
- Los eosinófilos son células inflamatorias clave en el asma, pero su papel preciso no está claro.
- Comprender la función de los eosinófilos es vital para el tratamiento de enfermedades alérgicas y otras afecciones.
Objetivo del estudio:
- Para investigar el papel específico de los eosinófilos en la patogénesis del asma.
- Desarrollar una herramienta para el estudio de enfermedades relacionadas con los eosinófilos.
Principales métodos:
- Creación de una línea de ratón transgénico (PHIL) que carece de eosinófilos.
- Desafío alérgeno en ratones PHIL para evaluar las respuestas relacionadas con el asma.
Principales resultados:
- Los eosinófilos eran esenciales para la acumulación de moco en los pulmones.
- La hipersensibilidad de las vías respiratorias en modelos de asma requería la presencia de eosinófilos.
Conclusiones:
- Los eosinófilos juegan un papel crítico en el desarrollo del asma, específicamente en la producción de moco y la constricción de las vías respiratorias.
- El modelo de ratón PHIL proporciona una plataforma novedosa para el estudio de enfermedades asociadas a los eosinófilos como alergias, infecciones parasitarias y cáncer.
Videos de Conceptos Relacionados
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:23Cholinergic Neurons: Neurotransmission
Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:23Cystic Fibrosis: Pathogenesis
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
01:18Amino Acid Catabolism
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...