Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Energy to Drive Translocation01:37

Energy to Drive Translocation

Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Temperature determines early-life success of burbot Lota lota eggs.

Journal of fish biology·2026
Same author

Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.

Nature communications·2026
Same author

Endometrial NCOR1 deficiency contributes to implantation failure in endometriosis-associated infertility.

iScience·2026
Same author

The PM20D1-OLE pathway induces microglia rewiring to ameliorate Alzheimer disease.

Cell death & disease·2026
Same author

Dynamics of genetic and somatic trade-offs in ageing and mortality.

Nature·2026
Same author

How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research.

Cell metabolism·2026

Video Experimental Relacionado

Updated: Jun 17, 2026

Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria
13:42

Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria

Published on: September 7, 2012

PGC-1alpha: turbocarga de las mitocondrias de las células

Sander M Houten1, Johan Auwerx

  • 1Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404 Illkirch, France.

Cell
|September 30, 2004
PubMed
Resumen

El estudio muestra que el PGC-1alpha es crucial para el metabolismo y la función muscular. También revela una sorprendente nueva función de PGC-1alfa en el cerebro.

Área de la Ciencia:

  • Regulación del metabolismo.
  • Biología mitocondrial Biología mitocondrial
  • La neurociencia es la neurociencia.

Sus antecedentes:

  • El PGC-1alpha (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) es un coactivador clave de la transcripción. es un coactivador clave de la transcripción.
  • Regula numerosos procesos metabólicos, incluida la producción de energía y el metabolismo de la glucosa.

Objetivo del estudio:

  • Para caracterizar las funciones de PGC-1alpha.
  • Para investigar el papel de PGC-1alpha en el cerebro.

Principales métodos:

  • Generación y análisis de ratones PGC-1alpha knockout (PGC-1alpha ((-/-)).
  • Evaluación de los parámetros metabólicos y la función cerebral.

Principales resultados:

Más Videos Relacionados

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly
09:53

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly

Published on: June 7, 2024

Videos de Experimentos Relacionados

Last Updated: Jun 17, 2026

Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria
13:42

Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria

Published on: September 7, 2012

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly
09:53

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly

Published on: June 7, 2024

  • Los ratones PGC-1alpha knockout exhiben defectos en la biogénesis mitocondrial y la respiración.
  • La pérdida de PGC-1alpha afecta la gluconeogénesis hepática y altera el tipo de fibra muscular.
  • Inesperadamente, la deficiencia de PGC-1alfa tiene un impacto en la función cerebral.

Conclusiones:

  • PGC-1alpha tiene funciones pleiotrópicas en el metabolismo y la fisiología muscular.
  • PGC-1alpha juega un papel crítico y previamente no reconocido en el sistema nervioso central.