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La heredabilidad de la variabilidad de la frecuencia cardíaca ambulatoria

Nina H M Kupper¹, Gonneke Willemsen, Mireille van den Berg

¹Vrije Universiteit, Amsterdam, The Netherlands. hm.kupper@psy.vu.nl

|October 20, 2004

Resumen

La variabilidad de la frecuencia cardíaca (VRC) es altamente hereditaria. Los factores genéticos explican el 35-48% de la variación en la VRC ambulatoria, lo que sugiere su utilidad en los estudios genéticos de enfermedades cardiovasculares.

Área de la Ciencia:

Fisiología cardiovascular fisiología cardiovascular.
Genética del comportamiento Genética del comportamiento.

Sus antecedentes:

La variabilidad reducida de la frecuencia cardíaca (VRC) predice la enfermedad cardíaca y la mortalidad.
Comprender las fuentes de variabilidad de la VRC puede mejorar el diagnóstico y la prevención.
Las contribuciones genéticas y ambientales a la HRV durante el monitoreo ambulatorio naturalista siguen siendo poco estudiadas.

Objetivo del estudio:

Para investigar la heredabilidad de la variabilidad de la frecuencia cardíaca ambulatoria.
Para cuantificar las contribuciones genéticas y ambientales a la HRV durante el monitoreo prolongado.

Principales métodos:

Grabaciones de electrocardiograma ambulatorio (ECG) durante 24 horas en 772 gemelos y hermanos sanos.
Análisis de las medidas de HRV en el dominio temporal: índice SDNN y RMSSD.
Análisis genéticos multivariados en diferentes períodos diurnos.

Principales resultados:

Contribuciones genéticas significativas para el índice medio ambulatorio de SDNN (35-47%) y RMSSD (40-48%).
Las estimaciones de heredabilidad variaron a lo largo de los períodos diurnos.
Las diferencias individuales en la VRC están sustancialmente influenciadas por factores genéticos.

Conclusiones:

Las medidas ambulatorias de VHC son altamente hereditarias.
Estos hallazgos apoyan el uso de la HRV en estudios de asociación y vinculación genética.
La heredabilidad de la VRC ofrece información sobre las variaciones genéticas que afectan el riesgo de enfermedades cardiovasculares.

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