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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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La unión dependiente de la fosforilación de las ciclinas mitóticas a Cdc6 contribuye al control de la replicación del

Satoru Mimura1, Takashi Seki, Seiji Tanaka

  • 1Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3LD, UK.

Nature
|October 22, 2004
PubMed
Resumen

Las cinasas dependientes de ciclina (CDK) previenen la replicación del ADN al unirse a Cdc6, una proteína clave en la replicación del ADN. Esta interacción, mediada por la ciclina Clb2, inhibe el ensamblaje del complejo pre-replicativo durante la división celular.

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