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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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Hormona del crecimiento humano y dominio extracelular de su receptor: estructura cristalina del complejo complejo

A M de Vos1, M Ultsch, A A Kossiakoff

  • 1Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080.

Science (New York, N.Y.)
|January 17, 1992
PubMed
Resumen

La hormona del crecimiento humano (hGH) se une a su receptor en una proporción de 1:2, revelando una estructura de haz de cuatro hélices única. Esta interacción es clave para la regulación del crecimiento e implica la dimerización secuencial del receptor para la transducción de señales.

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