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Updated: Jul 6, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
13:40

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

Published on: July 7, 2011

El silenciamiento terapéutico de un gen endógeno mediante la administración sistémica de siRNAs modificados

Jürgen Soutschek1, Akin Akinc, Birgit Bramlage

  • 1Alnylam Europe AG, Fritz-Hornschuch-Str. 9, 95326 Kulmbach, Germany. jsoutschek@alnylam.de

Nature
|November 13, 2004
PubMed
Resumen

Los ARN cortos de interferencia modificados químicamente (siRNA) silenciaron eficazmente los genes de la apolipoproteína B (apoB) en ratones después de la inyección intravenosa. Este avance demuestra el potencial terapéutico de la interferencia del ARN para el tratamiento de enfermedades causadas por objetivos no farmacológicos.

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