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Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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The Movement of Organelles and Vesicles

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Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.

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Updated: May 7, 2026

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay

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Published on: October 19, 2012

El filtrado SNARE por dinamina.

Bruno Antonny¹

¹Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice, 06560 Valbonne, France.

|November 20, 2004

Resumen

Este resumen es generado por máquina.

La mecanoenzima dinamina, conocida por la fisión de la membrana, también puede preparar las membranas para la fusión. Este estudio revela un doble papel para la dinamina en la dinámica del tráfico de membranas.

Área de la Ciencia:

Biología celular Biología celular.
Dinámica de las membranas.
La función de las proteínas Función de las proteínas.

Sus antecedentes:

El tráfico de membranas implica la fisión y la fusión.

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La dinamina es una proteína clave en la fisión de la membrana.