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Normalización de la vasculatura tumoral: un concepto emergente en la terapia antiangiogénica
1E. L. Steele Lab for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Cox-7, 100 Blossom Street, Boston, MA 02114, USA. jain@steele.mgh.harvard.edu.
Science (New York, N.Y.)
|January 8, 2005
Resumen
Ciertos medicamentos antiangiogénicos pueden normalizar la vasculatura tumoral, mejorando el suministro de oxígeno y nutrientes. Esta normalización vascular puede mejorar las terapias contra el cáncer al aliviar la hipoxia y aumentar la eficacia del medicamento.
Área de la Ciencia:
- Oncología Oncología.
- Biología Vascular Biología Vascular
- Desarrollo de Drogas Desarrollo de Drogas.
Sus antecedentes:
- Los tumores sólidos dependen de la vasculatura tumoral para su crecimiento y supervivencia.
- Las terapias antiangiogénicas actuales tienen como objetivo principal destruir los vasos sanguíneos tumorales.
- Se cree que esta destrucción priva a los tumores de oxígeno y nutrientes.
Objetivo del estudio:
- Revisar la evidencia emergente para una hipótesis alternativa sobre los agentes antiangiogénicos.
- Para explorar el concepto de normalización vascular en la vasculatura tumoral.
- Discutir las posibles implicaciones terapéuticas de la normalización vascular.
Principales métodos:
- Revisión de la literatura científica existente y los hallazgos de la investigación.
- Análisis de datos sobre los efectos de agentes antiangiogénicos específicos en la vasculatura tumoral.
- Síntesis de la evidencia que apoya la hipótesis de la normalización vascular.
Principales resultados:
- Ciertos agentes antiangiogénicos pueden normalizar transitoriamente la vasculatura tumoral anormal.
- La normalización vascular mejora la eficiencia del suministro de oxígeno y nutrientes a los tumores.
- La vasculatura normalizada puede aliviar la hipoxia tumoral y mejorar la administración de medicamentos.
Conclusiones:
- Las terapias antiangiogénicas pueden tener una doble función: destrucción y normalización de la vasculatura tumoral.
- La normalización vascular puede mejorar la eficacia de los tratamientos convencionales contra el cáncer cuando se programan cuidadosamente.
- La comprensión de los mecanismos de normalización vascular podría conducir a mejores terapias para el cáncer y otras enfermedades que involucran una vasculatura anormal, incluida la medicina regenerativa.
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