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Quimioterapia de gusanos parásitos: nuevas estrategias bioquímicas
Science (New York, N.Y.)
|August 3, 1979
Resumen
Los gusanos planos parásitos utilizan receptores de serotonina para regular el movimiento y el metabolismo. Dirigirse a estos receptores con nuevos agentes quimioterapéuticos ofrece una estrategia prometedora para el tratamiento de las infecciones por helmintos.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Parasitología Parasitología.
- Farmacología Farmacología.
Sus antecedentes:
- Los agentes quimioterapéuticos dirigidos a los helmintos parásitos a menudo afectan a los sitios reguladores celulares.
- Los receptores de serotonina están implicados en la regulación de la motilidad y el metabolismo de los carbohidratos en los parásitos gusanos planos.
- Estos receptores están acoplados a la adenilato ciclasa a través de un componente dependiente del trifosfato de guanosina en Fasciola hepatica.
Objetivo del estudio:
- Para investigar el papel de los receptores de serotonina en las lombrices planas parásitas.
- Para identificar posibles dianas quimioterapéuticas para las infecciones por helmintos.
Principales métodos:
- Estudió la actividad de los receptores de serotonina en gusanos planos parásitos.
- Agonistas y antagonistas identificados para los receptores de serotonina.
Principales resultados:
- Los receptores de serotonina regulan la motilidad y el metabolismo de los carbohidratos en Fasciola hepatica.
- La serotonina actúa como un potente agonista de la indoleamina.
- La dietilamida del ácido lisérgico y su derivado 2-bromo son potentes antagonistas.
Conclusiones:
- Los receptores de serotonina representan objetivos potenciales para los nuevos agentes quimioterapéuticos contra los trematodos.
- La comprensión de estos sitios reguladores puede conducir a un desarrollo de fármacos más selectivos para las infecciones por helmintos.
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