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Updated: Jul 6, 2026
06:00
One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
Published on: January 15, 2018
Transnitrosation de nitrosothiols: la caracterización de un elusivo intermedio esquivo
Laura L Perissinotti1, Adrián G Turjanski, Darío A Estrin
1Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, (C1428EHA) Buenos Aires, Argentina.
Journal of the American Chemical Society
|January 13, 2005
Resumen
Los investigadores investigaron las reacciones de transnitrozación utilizando ésteres etílicos de cisteína. La evidencia apoya un intermediario de disulfuro de nitróxilo en solución, avanzando nuestra comprensión de estos procesos biológicos.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- La cinética química es la cinética química.
Sus antecedentes:
- Las reacciones de transnitrosado son cruciales en los sistemas biológicos.
- Comprender los mecanismos de estas reacciones es vital para la relevancia fisiológica.
Objetivo del estudio:
- Investigar la reacción entre el éster etílico de (S) -nitroso-l-cisteína y el éster etílico de l-cisteína.
- Para modelar los procesos de transnitrosation fisiológicamente relevantes.
- Para identificar los intermediarios de reacción.
Principales métodos:
- Utilizó una combinación de cálculos teóricos y técnicas experimentales.
- Analizó la cinética de la reacción y los productos.
Principales resultados:
- Proporcionó evidencias teóricas y experimentales claras.
- Apoyó la existencia de un intermediario de disulfuro de nitróxilo en solución.
Conclusiones:
- El estudio aclara un intermediario clave en las reacciones de transnitrosamiento.
- Confirma el papel del intermediario del disulfuro de nitróxilo en el sistema modelo investigado.
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