El nivel de glucosa sérica en ayunas y el riesgo de cáncer en hombres y mujeres coreanos
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Sun Ha Jee1, Heechoul Ohrr, Jae Woong Sull
1Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yumc.yonsei.ac.kr
JAMA
|January 13, 2005
Resumen
El aumento de la glucosa sérica en ayunas y la diabetes son factores de riesgo independientes para varios cánceres importantes en Corea. Los niveles más altos de glucosa se correlacionan con un mayor riesgo de cáncer, particularmente para el cáncer de páncreas.
Área de la Ciencia:
- Endocrinología y Oncología.
- Epidemiología y Salud Pública.
Sus antecedentes:
- La diabetes mellitus es un creciente problema de salud mundial con un impacto económico significativo.
- La asociación entre la diabetes y el riesgo de cáncer sigue siendo incompletamente entendida.
Objetivo del estudio:
- Investigar el vínculo entre los niveles de glucosa sérica en ayunas, el diagnóstico de diabetes y el riesgo de desarrollar varios tipos de cáncer.
- Para analizar el riesgo de cáncer en relación con los niveles de glucosa entre los hombres y mujeres coreanos.
Principales métodos:
- Un estudio de cohorte prospectivo de 10 años en el que participaron más de 1,29 millones de coreanos de entre 30 y 95 años.
- Datos recogidos a partir de evaluaciones médicas bienal entre 1992-1995, con la incidencia del cáncer y la mortalidad como puntos finales.
- Análisis estadístico utilizando modelos de peligros proporcionales de Cox, controlando el tabaquismo y el consumo de alcohol.
Principales resultados:
- El aumento de la glucosa sérica en ayunas (> o = 140 mg / dl) se asoció con un aumento de la mortalidad por todos los tipos de cáncer en hombres y mujeres.
- La asociación más fuerte se observó para el cáncer de páncreas, con riesgos significativamente más altos en individuos con glucosa elevada.
- También se encontraron asociaciones significativas para los cánceres de esófago, hígado, colon / recto, cuello uterino y conducto biliar, con tendencias de riesgo creciente observadas con niveles más altos de glucosa.
Conclusiones:
- El aumento de la glucosa en suero en ayunas y un diagnóstico de diabetes son factores de riesgo independientes para múltiples cánceres importantes en la población coreana.
- Existe una relación dosis-respuesta, donde los niveles más altos de glucosa sérica en ayunas corresponden a un mayor riesgo de cáncer.
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