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A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
Published on: August 21, 2019
El sombreado filogenético y la identificación computacional de los genes de microARN humanos
Cell
|January 18, 2005
Resumen
Los investigadores descubrieron numerosos microARN novedosos (miRNA) en el genoma humano mediante el análisis de especies de primates. Este estudio revela patrones clave de conservación en los genes de miRNA, ayudando a futuros descubrimientos.
Área de la Ciencia:
- La genómica es la genómica.
- La bioinformática es la bioinformática.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Los microARN (miRNA) son pequeños ARN no codificantes que regulan la expresión génica.
- Comprender la conservación de genes de miRNA en todas las especies es crucial para identificar los elementos funcionales.
- Es posible que las estimaciones anteriores hayan subestimado el repertorio completo de miRNA humanos.
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01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...