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Fases cúbicas y dispersiones de fases cúbicas en un sistema basado en fosfolípidos
Markus Johnsson1, Justas Barauskas, Fredrik Tiberg
1Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se
Journal of the American Chemical Society
|January 27, 2005
Resumen
Este estudio caracteriza un sistema de fase cristalina líquida cúbica utilizando dioleoilfosfatidiletanolamina (DOPE) y monooleato de glicerol PEGilado (PEG660-OGM). El sistema forma partículas coloidales con una estructura de fase cúbica estable, incluso en condiciones diluidas.
Área de la Ciencia:
- Ciencia de los materiales Ciencia de los materiales.
- La biofísica es la biofísica.
- Química Física es la química física.
Sus antecedentes:
- Las fases cristalinas líquidas basadas en fosfolípidos son cruciales en varias aplicaciones.
- La dioleoilfosfatidiletanolamina (DOPE) es un fosfolípido común para la formación de estas fases.
- Estabilizar estas fases, especialmente en formas coloidales, sigue siendo un desafío.
Objetivo del estudio:
- Para caracterizar un nuevo sistema cúbico de fase cristalina líquida.
- Para investigar el efecto del monooleato de glicerol PEGilado (PEG(660)-OGM) en las fases cúbicas a base de DOPE.
- Para explorar la formación de partículas coloidales de este sistema.
Principales métodos:
- Preparación del sistema utilizando DOPE, PEG660 y agua.
- Análisis del comportamiento de fase a través de diferentes concentraciones.
- Caracterización de la estructura de fase cúbica y la formación de partículas.
Principales resultados:
- Se formó una fase cristalina líquida cúbica estable por el sistema DOPE/PEG(660)-OGM/agua.
- La fase cúbica coexiste con el agua en regiones diluidas del diagrama de fase.
- El sistema puede fragmentarse en partículas coloidales que conservan la estructura de fase cúbica.
Conclusiones:
- La adición de PEG660-OGM estabiliza la fase cristalina líquida cúbica a base de DOPE.
- Este sistema ofrece un método para crear nanopartículas estables de fase cúbica.
- Se sugieren aplicaciones potenciales en la administración de fármacos y la ciencia de los materiales.
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