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Potente efecto inhibidor del sirolimus en las células progenitoras vasculares circulantes
Daiju Fukuda1, Masataka Sata, Kimie Tanaka
1Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Circulation
|February 16, 2005
Resumen
Los stents que emiten sirolimus previenen la restenosis del stent al inhibir las células progenitoras del músculo liso circulante. Sin embargo, el sirolimus también puede impedir la reendotelialización después de la implantación de un stent.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Biología Vascular Biología Vascular
- Farmacología Farmacología.
Sus antecedentes:
- La hiperplasia neointimal es la causa principal de la restenosis en el stent (ISR).
- Los stents que emiten sirolimus (SES) son prometedores para prevenir la ISR, pero el mecanismo no está claro.
- Las células progenitoras circulantes están implicadas en la formación de neointimales.
Objetivo del estudio:
- Investigar el mecanismo por el cual el sirolimus previene la RSI.
- Para determinar el efecto del sirolimus en las células progenitoras circulantes.
Principales métodos:
- Células mononucleares aisladas de voluntarios sanos.
- MNCs cultivadas para inducir células similares al músculo liso (SM) y células similares a las células endoteliales.
- Sirolimus administrado a células en cultivo y arterias femorales lesionadas de ratón.
Principales resultados:
- Sirolimus inhibió potentemente el crecimiento de células tipo SM de las multinacionales.
- El sirolimus redujo la hiperplasia neointimal en modelos de ratón.
- Sirolimus disminuyó las células hematopoiéticas y de tipo SM derivadas de la médula ósea en lesiones.
- Sirolimus retrasó la reendotelización en las arterias tratadas.
Conclusiones:
- La inhibición de Sirolimus de las células progenitoras del músculo liso circulante probablemente contribuye a la eficacia del SES.
- Sirolimus puede tener un impacto negativo en la reendotelialización después de la colocación de un stent.
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