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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Se requiere una nueva proteasa cisteína heterodimérica para el procesamiento de la interleucina-1 beta en monocitos

N A Thornberry1, H G Bull, J R Calaycay

  • 1Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065.

Nature
|April 30, 1992
PubMed
Resumen

Los investigadores identificaron la enzima de conversión de la interleucina-1 beta (IL-1 beta), una proteasa de cisteína y diseñaron inhibidores. El bloqueo de esta enzima en los monocitos detiene la producción madura de IL-1 beta, lo que lo sugiere como un objetivo terapéutico para la inflamación.

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