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La fosfolipasa Cgamma1 controla la expresión superficial de TRPC3 a través de un dominio PH intermolecular

Damian B van Rossum1, Randen L Patterson, Sumit Sharma

  • 1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Nature
|March 4, 2005
PubMed
Resumen

Los científicos descubrieron un nuevo mecanismo de señalización que involucra canales iónicos y unión lipídica. Un dominio de homología parcial de pleckstrina (PH) en PLC-gamma1 interactúa con los canales TRPC3, regulando la entrada de calcio y la expresión de la superficie celular.

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