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Participación de la nucleobasa en la catálisis de la ribozima.

Zheng-Yun Zhao1, Aileen McLeod, Shinya Harusawa

  • 1CR-UK Nucleic Acid Structure Research Group, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, UK.

Journal of the American Chemical Society
|April 7, 2005
PubMed
Resumen

Los investigadores modificaron la ribozima VS mediante la sustitución de la adenina por un anillo de imidazol. Esta nueva ribozima cataliza eficientemente las reacciones de escisión y ligadura, lo que sugiere la participación de la nucleobasa en su mecanismo.

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