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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
La reaparición del Staphylococcus aureus pandémico temprano como un clon resistente a la meticilina adquirido por la
D Ashley Robinson1, Angela M Kearns, Anne Holmes
1Department of Biology and Biochemistry, University of Bath, Bath, UK.
Lancet (London, England)
|April 7, 2005
Resumen
El famoso clon del fago Staphylococcus aureus tipo 80/81, una vez eliminado, está resurgiendo. Los descendientes muestran resistencia a la meticilina y están vinculados a infecciones adquiridas en la comunidad.
Área de la Ciencia:
- Microbiología Microbiología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Genética La genética.
Sus antecedentes:
- El clon del fago Staphylococcus aureus tipo 80/81 resistente a la penicilina causó importantes infecciones mundiales en la década de 1950.
- Este clon fue erradicado en gran medida en la década de 1960 debido a la introducción de los antibióticos beta-lactámicos resistentes a la penicilinasa.
Objetivo del estudio:
- Para investigar la presencia de genes de leucocidina de Panton-Valentine en aislamientos de principios de los años 80/81.
- Para determinar la trayectoria evolutiva y la prevalencia actual del linaje 80/81.
Principales métodos:
- El análisis de la secuencia de multilocus se empleó para rastrear el linaje genético de Staphylococcus aureus.
- Se analizaron los aislados para detectar la presencia de genes específicos de virulencia, incluida la leucocidina de Panton-Valentine.
Principales resultados:
- Los descendientes del clon 80/81 han adquirido resistencia a la meticilina.
- El linaje 80/81 está resurgiendo como una causa significativa de infecciones adquiridas en la comunidad.
- Este clon reemergente representa un linaje distinto estrechamente relacionado con las cepas de MRSA pandémicas adquiridas en el hospital.
Conclusiones:
- El clon 80/81 Staphylococcus aureus está evolucionando y reemergiendo con resistencia a la meticilina.
- Este resurgimiento plantea una amenaza renovada para las infecciones adquiridas en la comunidad.
- Comprender las adaptaciones genéticas de este clon es crucial para las intervenciones de salud pública.
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