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Updated: Jul 19, 2026

Isolation of Labile Multi-protein Complexes by in vivo Controlled Cellular Cross-Linking and Immuno-magnetic Affinity Chromatography
10:50

Isolation of Labile Multi-protein Complexes by in vivo Controlled Cellular Cross-Linking and Immuno-magnetic Affinity Chromatography

Published on: March 9, 2010

Estabilización cinética de una proteína oligomérica por un solo evento de unión al ligando

R Luke Wiseman1, Steven M Johnson, Matthew S Kelker

  • 1Department of Chemistry, the Department of Molecular Biology, and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 265, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|April 14, 2005
PubMed
Resumen

La estabilización de los tetrámeros de transtiretina (TTR) previene la enfermedad amiloide. Atar un inhibidor al TTR es suficiente para bloquear la disociación y el desensamblaje, incluso con un solo sitio de unión ocupado.

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