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espesor de la pared aórtica en recién nacidos con restricción del crecimiento intrauterino
Michael R Skilton1, Nick Evans, Kaye A Griffiths
1Department of Medicine, University of Sydney, Sydney, Australia.
Lancet (London, England)
|April 27, 2005
Resumen
Los recién nacidos con restricción del crecimiento intrauterino muestran una aorta más gruesa, lo que indica una aterosclerosis temprana. Esto sugiere que los factores prenatales pueden aumentar el riesgo futuro de enfermedad cardiovascular en estos bebés.
Área de la Ciencia:
- Ciencias Cardiovasculares Ciencias Cardiovasculares
- Salud Neonatal La salud neonatal es la salud neonatal.
- Epidemiología La epidemiología.
Sus antecedentes:
- Los estudios epidemiológicos vinculan el bajo peso al nacer con un mayor riesgo de enfermedad cardiovascular más adelante en la vida.
- La restricción del crecimiento intrauterino (IUGR) es una preocupación significativa en la salud neonatal.
- Los marcadores tempranos de aterosclerosis en los recién nacidos podrían predecir futuros eventos cardiovasculares.
Objetivo del estudio:
- Para investigar el grosor de la pared aórtica en recién nacidos con y sin restricción del crecimiento intrauterino.
- Para determinar si el engrosamiento de la aorta en los recién nacidos IUGR es un marcador de aterosclerosis temprana.
- Para explorar los orígenes prenatales del riesgo cardiovascular.
Principales métodos:
- Se utilizó la ecografía para medir el grosor de la pared aórtica en 25 recién nacidos con IUGR y 25 controles.
- Las mediciones incluyeron el grosor máximo de la aorta y el grosor ajustado al peso al nacer.
- El análisis estadístico comparó el grosor aórtico entre los dos grupos.
Principales resultados:
- Los recién nacidos con IUGR tenían un grosor aórtico máximo significativamente mayor (810 μm) en comparación con los controles (743 μm).
- El espesor aórtico ajustado por el peso al nacer fue sustancialmente mayor en el grupo de IUGR (300 μm/kg) frente a los controles (199 μm/kg).
- Estos hallazgos fueron estadísticamente significativos (p=0,02 para el grosor máximo, p<0,0001 para el grosor ajustado).
Conclusiones:
- Los recién nacidos que experimentan restricción del crecimiento intrauterino exhiben un engrosamiento aórtico significativo.
- Este engrosamiento de la aorta sugiere la presencia de aterosclerosis temprana.
- Los eventos prenatales asociados con IUGR pueden predisponer a los bebés a un riesgo cardiovascular posterior.
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