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Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Nucleic Acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

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Video Experimental Relacionado

Updated: May 8, 2026

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

El papel de Ro en el reconocimiento de ARN.

Ian J MacRae1, Jennifer A Doudna1

  • 1Howard Hughes Medical Institute, Department of Molecular & Cell Biology  and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720.

Cell
|May 24, 2005
PubMed
Resumen

El autoantígeno Ro 60 kDa juega un papel en el control de calidad del ARN pequeño al unirse a ARN mal plegados. Las estructuras cristalinas revelan distintos sitios de unión de ARN, lo que explica cómo Ro diferencia entre los ARN pequeños nativos y los mal plegados.

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Biología Estructural Biología estructural.
  • La bioquímica es la bioquímica.

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Last Updated: May 8, 2026

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
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Sus antecedentes:

  • El autoantígeno Ro 60 kDa está implicado en procesos celulares que involucran pequeñas moléculas de ARN.
  • Su función precisa en el metabolismo del ARN y el control de calidad sigue siendo incompletamente entendida.
  • Comprender la interacción de Ro con el ARN es crucial para descifrar su papel en la salud celular.