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El factor de crecimiento placentario promueve el engrosamiento íntimo aterosclerótico y la acumulación de macrófagos
Rohit Khurana1, Lieve Moons, Shahida Shafi
1BHF Laboratories, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, United Kingdom.
Circulation
|May 25, 2005
Resumen
El factor de crecimiento placentario (PlGF) promueve la aterosclerosis al aumentar el engrosamiento íntimo y la acumulación de macrófagos. La deficiencia de PlGF reduce el desarrollo de lesiones ateroscleróticas, lo que indica su papel crucial en la enfermedad.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Inmunología Inmunología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El factor de crecimiento placentario (PlGF) está relacionado con la angiogénesis y el reclutamiento de monocitos en enfermedades inflamatorias.
- Su papel específico en la aterosclerosis, una condición inflamatoria crónica, permaneció sin examinar.
Objetivo del estudio:
- Investigar el impacto del PlGF exógeno en el desarrollo de la aterosclerosis.
- Para determinar el efecto de la deficiencia de PlGF en las condiciones ateroscleróticas existentes.
Principales métodos:
- La transferencia de genes adenovirales se utilizó para administrar PlGF a las arterias carótidas de conejos.
- La aterosclerosis se estudió en ratones con deficiencia de apolipoproteína E (apoE(-/-)) con y sin deficiencia de PlGF.
Principales resultados:
- La administración de PlGF adenoviral aumentó el engrosamiento íntimo, la acumulación de macrófagos y la neovascularización en las arterias del conejo.
- La deficiencia de PlGF redujo el tamaño y el contenido de macrófagos de las lesiones ateroscleróticas tempranas en ratones apoE.
- Se observó un aumento de la expresión del receptor PlGF Flt-1 en los macrófagos neointimales.
Conclusiones:
- La administración local de PlGF exacerba la formación de neointima aterogénica en conejos con hipercolesterolemia.
- PlGF es esencial para la infiltración de los macrófagos en las lesiones ateroscleróticas tempranas.
- Estos hallazgos ponen de relieve un nuevo papel para PlGF en la patogénesis de la aterosclerosis.
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